Waldenström's macroglobulinemia is a rare disease whose pathophysiology remains at present
poorly understood, although a recurrent mutation (L265P MYD88) has recently been described.
Unlike other lymphoproliferative disorders, there is a defect in isotype switching, mechanism
involving AID and NHEJ complex. Using a two-dimensional electrophoresis technology, our group
showed that MW had a specific proteomic profile, and one of the differentially expressed
proteins is Ku70 (encoded by XRCC6 belonging to NHEJ complex) .
The investigators purpose to explore the mechanisms of underexpression of Ku70/XRCC6 (genetic
or epigenetic modification) in comparison with other lymphoid malignancies and normal B