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More info
You can access this
clinical trial
if you have
Waldenström Macroglobulinemia
and you are
over 18
years old
-
The phase for this study is not defined.
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The purpose

Waldenström's macroglobulinemia is a rare disease whose pathophysiology remains at present poorly understood, although a recurrent mutation (L265P MYD88) has recently been described. Unlike other lymphoproliferative disorders, there is a defect in isotype switching, mechanism involving AID and NHEJ complex. Using a two-dimensional electrophoresis technology, our group showed that MW had a specific proteomic profile, and one of the differentially expressed proteins is Ku70 (encoded by XRCC6 belonging to NHEJ complex) . The investigators purpose to explore the mechanisms of underexpression of Ku70/XRCC6 (genetic or epigenetic modification) in comparison with other lymphoid malignancies and normal B cells.

Provided treatments

  • Biological: Blood or bone marrow samples
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Locations near you

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Tris trial is registered with FDA with number: NCT02640287. The sponsor of the trial is Central Hospital, Nancy, France and it is looking for 80 volunteers for the current phase.
Official trial title:
Expression of Ku70/XRCC6 and Others NHEJ Components in Waldenström's Macroglobulinemia in Comparison With Others B-cell Lymphoproliferative Disorders and Normal B Cells.