The objective of our observational prospective study will be to compare, for women treated
for infertility and included in a ICSI program, the implantation rate and delivery rate
obtained after the transfer of a single blastocyst , chosen in a group of patients on the
basis of the embryo morphology and in the other group on the basis of both embryo morphology
and follicular fluid cytokines content.
100 IVF infertile patients , aged 32-39 years, with normal ovarian reserve, previously
stimulated for their first cycle with standard short protocol (GnRH-Ant) and r-FSH alone, who
have had a low ovarian response, Fort < 50% ( FORT Criteria, 2012; FORT= PFCX100/AFC), will
be treated for the second cycle with standard short protocol (GnRH-Ant) and r-FSH plus r-LH ,
according to the standard established by our clinical practice.
Patients will be part of one of the following groups:
Group 1: single embryo transfer on day 5, according to standard embryo morphological criteria
Group 2: single embryo transfer on day 5, chosen on the basis of both embryo morphological
criteria and levels of cytokines measured in the individual FF.