This randomized pilot clinical trial studies topical cryotherapy (cooling hands and feet with
ice bags) in reducing pain in patients with chemotherapy induced peripheral neuropathy or
paclitaxel induced acute pain syndrome. Peripheral neuropathy is a nerve problem that causes
pain, numbness, tingling, swelling, or muscle weakness in different parts of the body.
Paclitaxel produces a disabling syndrome of acute aches and pains. Topical cryotherapy is
being studied to see if it can help relieve pain from peripheral neuropathy or acute pain
syndrome caused by chemotherapy.