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More info
You can access this
clinical trial
if you have
Hypoxia or Bone Resorption
and you are
between 25 and 45
years old
-
The phase for this study is not defined.
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The purpose

Bone losses are well known to occur in response to unloading (in microgravity or during immobilisation) and in patients with chronic obstructive airway disease (COPD). However, it is unknown whether there is an interactive effect between hypoxia and musculoskeletal unloading upon bone and mineral metabolism. Fourteen non-obese men, who are otherwise healthy, will undergo 3x 21-day interventions; normobaric normoxic bed rest (NBR; FiO2=21%), normobaric hypoxic ambulatory confinement (HAMB; FiO2=14%; ~4000 m simulated altitude), and normobaric hypoxic bed rest (HBR; FiO2=14%). The effects of hypoxia and bedrest on bone metabolism and phosphor-calcic homeostasis will be assessed (before and during each intervention, and 14 days after each intervention period) using venous blood sampling, 24hr urine collections, and peripheral quantitative computerized tomography (pQCT).

Provided treatments

  • Other: Hypoxia
  • Other: Ambulatory
  • Other: Normoxia
  • Other: Bed Rest
  • Other: Standardised nutritional intake

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02637921. The sponsor of the trial is University of Nottingham and it is looking for 14 volunteers for the current phase.
Official trial title:
Planetary Habitat Simulation: The Combined Effects of Bed Rest and Normobaric Hypoxia Upon Bone and Mineral Metabolism (WP3)