This research study will test how well one topical medications work to prevent the
development of non-melanoma skin cancers by reversing certain biomarkers in the skin. This
study is also looking at the optimal dose of a medication in a small number of people.
Biomarkers are molecules that are found in the body and inside of cells. Some biomarkers are
associated with specific diseases such as skin cancer. In this study, one topical medication
will be evaluated; diclofenac. Diclofenac and is approved by the Food and Drug Administration
(FDA) for other uses. 24 patients will be enrolled in this study by University of Alabama at