The present study aims to identify the mechanisms underlying the deficit in facial emotion
recognition reported both in schizophrenia and the 22q11.2 deletion syndrome, and thus,
reveal a distinction between the two disorders. Indeed, despite the clinical overlap between
the two syndromes, some of the symptoms appear to be specific to only one of them. In
particular, the disturbance of visual functions is specifically observed in the 22q11.2DS.
Hence, the difficulties in facial emotion recognition in schizophrenia and in the 22q11.DS
are likely accounted by different cognitive impairments. Investigating which mechanisms are
disturbed would allow a specialized support for patients.
Our main hypothesis is that the deficit in facial emotion recognition is more related to
visual impairments in the 22q11.2DS than in schizophrenia. This hypothesis will be tested in
two groups of patients (22q11.2DS and schizophrenic patients) and a control group (healthy
subjects) using an experimental paradigm based on electroencephalography (EEG).
A second aim of this study is to determine whether the severity of the two disorders'
symptoms is correlated with the cerebral response to facial expressions. To answer this
question, a set of clinical and neuropsychological tests will be conducted for each patient.