COPD is an inflammatory disease characterized by enhanced chronic airway and lung
inflammatory responses to noxious agents (e.g. smoke, pollutants) and progressive airflow
limitation. In COPD patients there is a spillover of peripheral lung inflammation into
systemic circulation resulting in increased level of various inflammatory markers such as:
IL-1β, IL-6, IL-8, and TNF-α.
Diagnosis, now, is based on clinical evaluation and spirometry test and COPD treatment
includes the use of LABA, LAMA and corticosteroids.
To data no plasmatic marker able to identify the stage of COPD and the response to the
treatment have been documented . The aim of this study is to evaluate in COPD patients the
role of microRNA as predictive biomarker, of the disease in order to have a signature of miRs
typically of COPD