Your journey
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More info
You can access this
clinical trial
if you have
Nasopharyngeal Carcinoma
and you are
between 18 and 65
years old
3
This is a trial in the final phase before the treatment is released on the market.
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The purpose

Currently, concurrent chemoradiotherapy with/without sequential chemotherapy is the standard treatment modality for intermediate risk NPC (stage II and T3N0M0) according to the National Comprehensive Cancer Network guideline. However these recommendations were based on the evidence in the two-dimensional conventional radiotherapy (2DCRT) era. The introduction of intensity-modulated radiotherapy (IMRT) in NPC treatment has brought substantial better treatment outcomes than 2DCRT. It has been questioned whether additional concurrent chemotherapy is still necessary for intermediate risk NPC within the excellent framework of IMRT. Thus, the investigators jointly conduct the first non-inferior randomized trial to determine the value of concurrent chemotherapy with cisplatin for intermediate risk NPC patients treated with IMRT. Given the results of clinical studies mentioned above,the investigators decide to adopt the concurrent regimen to be cisplatin 100 mg/m2 on day 1, 22, 43

Provided treatments

  • Radiation: IMRT
  • Drug: Cisplatin
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Locations near you

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Tris trial is registered with FDA with number: NCT02633202. The sponsor of the trial is Sun Yat-sen University and it is looking for 338 volunteers for the current phase.
Official trial title:
Prospective Non-inferior Clinical Trial Comparing Concurrent Chemoradiotherapy or Radiotherapy Alone in Patients With Intermediate Risk Nasopharyngeal Carcinoma in Intensity-modulated Radiotherapy Era