Interleukin-32 (IL-32) is a recently described cytokine that is a strong inducer of
pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α. A previous report have
reported that Porphyromonas gingivalis-derived LPS significantly up-regulated IL-32
expression compared with the unstimulated cells in monocytes (THP-1 cells). They suggested
that IL-32 may contribute to the pathogenesis of periodontal disease. In the present study
the investigators hypothesized that IL-32 levels may increase in the gingival crevicular
fluid (GCF) and saliva of patients with chronic periodontitis compared with healthy controls
and these levels may decrease together with treatment.