Objective: To randomly compare hysterectomy by vaginal Natural Orifice Transluminal
Endoscopic Surgery (vNOTES) versus laparoscopy uterus in women with benign gynecological
Study design: Randomized controlled/single
Study population: All women aged 18 to 70 years regardless of parity with a non-prolapsed
uterus and a benign indication for hysterectomy.
Primary study outcome parameters: successful removal of the uterus by the intended technique.
Secondary outcomes: the proportion of women admitted to the in-hospital ward; postoperative
pain scores; the total amount of analgesics used; postoperative infection; per- or
postoperative complications; hospital readmission rates; duration of the surgical procedure;
incidence and intensity of dyspareunia; sexual wellbeing; health-related quality of life;