The purpose of this study is to determine the effect of remote ischemic preconditioning
(RIPC) on blood pressure and its vascular protection effect among Chinese young healthy
adults and primary hypertensive patients stage I.
Procedure: Sham RIPC
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Full eligibility criteria for NCT02414997
Ages eligible for Study
18 Years to 80 Years
Genders eligible for Study
Accepts Healthy Volunteers
Subjects range from 18 to 80 years old.
Blood pressure is normal or primary hypertension stage I(systolic blood pressure 140 to 159 mmHg and/or diastolic blood pressure 90 to 99 mmHg).
No history of smoking( smoking can eliminate the effect of RIPC) or quit smoking for at least 1 years.
No intake of caffeine or caffeine-containing substances during the process of this trial(caffeine can eliminate the effect of RIPC).
Provide informed consent and willingness to cooperate with the study protocol.
Less than 18 years old or above 80 years old.
Pregnant or lactating females.
Systemic diseases such as diabetes, HIV/AIDS, liver disease, chronic renal failure, tuberculosis, and autoimmune diseases.
Medical history of cardiovascular disease: acute myocardial infarct, stable angina, unstable angina, heart failure, atrial fibrillation, atrioventricular blockade, peripheral vascular disease or cerebrovascular accident.
Patients who are unfavorable of long-term follow-up or poor compliance.
Patients who are considered unfavorable to take part in this trial by investigators.
All locations for NCT02414997
View full eligibility
Tris trial is registered with FDA with number: NCT02414997. The sponsor of the trial is First Affiliated Hospital, Sun Yat-Sen University and it is looking for 120 volunteers for the current phase.
Official trial title: The Effect of Remote Ischemic Preconditioning (RIPC) on Blood Pressure and Its Vascular Protection Effect Among Chinese Young Healthy Adults and Primary Hypertensive Patients Stage I
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