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More info
You can access this
clinical trial
if you have
Metastatic Melanoma
and you are
over 18
years old
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

This is a single arm explorative phase II clinical trial in 90 subjects with advanced stage melanoma harbouring a BRAFV600 mutation. PET imaging and molecular diagnostics are combined in order to monitor response to treatment with vemurafenib plus cobimetinib, examine development of resistance and correlate changes in metabolic/proliferative activity with extend of target inhibition.

Provided treatments

  • Drug: Vemurafenib plus cobimetinib
  • Device: Positron Emission Tomography
  • Procedure: Tissue sampling
  • Procedure: Blood sampling
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Tris trial is registered with FDA with number: NCT02414750. The sponsor of the trial is Netherlands Working Group on Immunotherapy of Oncology and it is looking for 90 volunteers for the current phase.
Official trial title:
A Phase II, Open-Label, Multicenter Study of Vemurafenib Plus Cobimetinib (GDC-0973) in Unresectable Stage IIIc or Stage IV Melanoma; Response Monitoring and Resistance Prediction With Positron Emission Tomography and Tumor Characteristics