Despite being a miracle of modern medicine, solid organ transplant recipients are always at
risk of rejection, and remain dependent on lifelong immunosuppression. Currently used
immunosuppressive drugs suppress the potential of immune system and interfere with the
metabolism of medications. Cellular therapies currently being investigated for this purpose
require the use of ablative radiotherapy. The investigators are using a less toxic strategy
by harnessing the immunosuppressive potential of the MSCs in the Kidney Transplant (KTx)
recipients and studying immunomodulation mediated by these cells in the KTx patients.
Hypothesis MSCs interfere with signalling of Immune cells like T cells, B cells and Dendritic
cells which leads to improve graft survival of renal transplant patients.
Aim To investigate effect of MSCs on immune cell repertoire in a donor specific mediated
The investigators aim to collect peripheral blood from 30 patients (10 patients for
autologous cell infusion and 10 for allogeneic (donor derived cell infusion) at various time
intervals following MSC therapy. 10 patients serve as controls on standard dose of drugs but
without MSC infusion. This peripheral blood would be utilized for isolation of mononuclear
cells and performing various immune assays on these cells in a donor specific response.