This trial is completed!
Search for a recruiting clinical trial for your condition
You can access this
clinical trial
if you have
Healthy
and you are
over 18
years old
0
This is an early phase trial to investigate
how or whether the drug affects your body.
Show me locations

The purpose

Regional brain glucose hypometabolism occurs during aging and may contribute to the onset of aging-related cognitive impairment in humans. Ketones are the main alternative energy substrate to glucose for the brain. Several studies show that brain ketone uptake and metabolism are unaltered in cognitively-normal older persons and in Alzheimer's disease (AD). Nutritional ketosis is reported to have a positive impact on cognitive performances in mild cognitive impairment and AD. Nevertheless, changes in regional brain glucose and ketone uptake in adults are poorly understood during diet-induced experimental ketosis. The investigators hypothesis was that during diet-induced ketosis, brain ketone uptake would be directly correlated with the elevation of blood ketone levels and inversely correlated to brain glucose uptake.

Provided treatments

  • Dietary: Ketogenic diet
Tris trial is registered with FDA with number: NCT02409784. The sponsor of the trial is Université de Sherbrooke and it is looking for 10 volunteers for the current phase.
Official trial title:
PET Study of Cerebral Metabolism of 11C-acetoacetate and 18F-FDG in Patients Under Moderate Ketosis