The study researchers want to look at the overall effects that Metformin may have on the
tumor characteristics of Head and Neck cancer cells as well as the interactions that
Metformin has on the growth or death of tumor cells.
We will connect you to the doctor responsible for this trial and help you get more information.
Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT02402348
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Newly diagnosed HNSCC Stage II-IVB (T1N1-3, T2-3, N0-3, M0) OR Patients with suspected Stage II-IVB tumor as determined by clinical examination or noted via imaging.
Planned complete resection of the primary tumor.
Age >= 18 years.
ECOG performance status of 0 or 1
Adequate hepatic, renal, and bone marrow function
Prior therapy for head and neck cancer
Candidates for neo-adjuvant chemotherapy or chemo-radiation therapy for curative intent.
Co-existing malignancy or malignancies diagnosed within the last 3 years with the exception of basal cell carcinoma or in situ cervical cancer.
History of diabetes mellitus or taking any medications indicated for diabetes mellitus treatment
Contraindication to metformin including hypersensitivity or allergic reaction
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
Pregnant or breastfeeding women are excluded from this study
All locations for NCT02402348
United States (1)
West Virginia University Hospitals - Mary Babb Randolph Cancer Center
Morgantown, West Virginia, United States, 26506
View full eligibility
Tris trial is registered with FDA with number: NCT02402348. The sponsor of the trial is West Virginia University and it is looking for 3 volunteers for the current phase.
Official trial title: Pilot Study of Metformin (MF) IN HNSCC (Head and Neck Squamous Cell Carcinoma) as Window Trial Design in Operable HNSCC, to Investigate the Effects of MF, Tumor Genotype and MF Genotype Interactions, on Tumor Metabolism and Anoikis
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