Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Leukemia or Lymphoma
and you are
under 21
years old
This is a second phase trial assessing
efficacy and side effects of the new treatment.
Show me locations

The purpose

In this study, participants with high-risk hematologic malignancies undergoing hematopoietic cell transplantation (HCT), who do not have a suitable human leukocyte antigen (HLA) matched related/sibling donor (MSD) or matched unrelated donor (MUD) identified, will receive a haploidentical donor HCT with additional natural killer (NK) cells. The investigators anticipate enrollment of 75 donors and 75 recipients. PRIMARY OBJECTIVE: - To estimate the rate of successful engraftment at day +42 post-transplant in patients who receive haploidentical donor stem cell plus NK cell transplantation with TLI based conditioning regimen for high risk hematologic malignancy. SECONDARY OBJECTIVES: - Estimate the incidence of malignant relapse, event-free survival, and overall survival at one-year post-transplantation. - Estimate incidence and severity of acute and chronic (GVHD). - Estimate the rate of transplant related mortality (TRM) in the first 100 days after transplantation.

Provided treatments

  • Radiation: Total Lymphoid Irradiation
  • Drug: Fludarabine
  • Drug: Cyclophosphamide
  • Drug: Thiotepa
  • Drug: Melphalan
  • Biological: HPC,A Infusion
  • Biological: TC-NK Infusion
  • Biological: G-CSF
  • Drug: Mesna
  • Device: CliniMACS
  • Drug: Mycophenolate mofetil
Wondering what is the locations section for?
We will connect you to the doctor responsible for this trial and help you get more information.

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01807611. The sponsor of the trial is St. Jude Children's Research Hospital and it is looking for 150 volunteers for the current phase.
Official trial title:
Haploidentical Donor Hematopoietic Progenitor Cell and Natural Killer Cell Transplantation With a TLI Based Conditioning Regimen in Patients With Hematologic Malignancies