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More info
You can access this
clinical trial
if you have
Extra-pancreatic Incretin Effect or Glucose Effectiveness
and you are
between 18 and 60
years old
The phase for this study is not defined.
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The purpose

Incretin hormones (GLP-1 and GIP) released from the intestine in response to meal ingestion augment insulin secretion from the pancreas to help maintain glycemic control. Studies in vitro and in vivo have shown that these incretin hormones also have functional effects in other tissues independent of the insulin secretory response. Both GLP-1 and GIP stimulate insulin secretion in a glucose-dependent manner, however the glucose-dependency of their extra-pancreatic effects has not been examined in vivo. By using pancreatic clamp methodology during euglycemic and hyperglycemic conditions we will test the hypothesis that extra-pancreatic effects of GLP-1 and GIP are glucose-dependent.

Provided treatments

  • Biological: Saline
  • Biological: GIP
  • Biological: GLP-1

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01749163. The sponsor of the trial is Rigshospitalet, Denmark and it is looking for 20 volunteers for the current phase.
Official trial title:
Determining the Extra-pancreatic Effects of Incretin Hormones During Euglycemic and Hyperglycemic Pancreatic Clamps