The purpose of this study is to investigate whether NXN-462, a selective nNOS inhibitor, is
effective in reducing pain levels in patients with post-herpetic neuralgia.
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Locations near you
Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Full eligibility criteria for NCT01748877
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Male, or a non-pregnant, non-lactating female 18 years or older
Have voluntarily provided written informed consent
able to speak, read, write, and understand English
clinical diagnosis of PHN for a minimum of 6 months
pain intensity score of ≥3 on a 0-10 Numerical Rating Scale (NRS) at the Screening Visit
generally in good health (other than PHN) at Screening
Are pregnant and/or lactating
Diagnosis of any chronic pain syndrome that would interfere with the assessment of PHN
evidence of multiple causes of neuropathic pain,e.g.lumbar radiculopathy in the lumbosacral area
Have had neuroablation or neurosurgical intervention for PHN
Have been taking opioid analgesics for >5 days/week
Have received nerve block or intrathecal analgesia within 6 weeks of the study
History of significant gastrointestinal disease, liver disease, renal disease, endocrine disease, or cardiovascular disease
clinically significant abnormal clinical laboratory test results or vital signs
Are immunocompromised or immunosuppressed for any reason
History of alcohol or other substance abuse (not including nicotine or tobacco) within 5 years
Significant psychiatric disorder which requires drug treatment (except depression or anxiety treated with Selective Serotonin Re-uptake Inhibitors)
Have received an investigational drug or have used an investigational device within 30 days of Screening.
Have previously been randomized to this study
All locations for NCT01748877
United States (22)
Phoenix, Arizona, United States, 85027
University of Southern California
Los Angeles, California, United States, 90033
Northern California Research
Sacramento, California, United States, 95821
Neurological Research Institute
Santa Monica, California, United States
Brooksville, Florida, United States, 34601
FPA Clinical Research
Kissimmee, Florida, United States, 34741
Suncoast Clinical Research
New Port Richey, Florida, United States
Compass Research LLC
Orlando, Florida, United States, 32806
Tampa, Florida, United States, 33606
Medex Healthcare Research, Inc.
Chicago, Illinois, United States, 60602
Integrated Clinical Trial Services
West Des Moines, Iowa, United States
Towson, Maryland, United States, 21204
Boston Clinical Trials
Boston, Massachusetts, United States, 02131
Michigan Head-Pain and Neurological Institute
Ann Arbor, Michigan, United States
Albuquerque Clinical Trials, Inc
Albuquerque, New Mexico, United States, 87102
Clinical Trials of America, Inc.
Hickory, North Carolina, United States, 01845
Lynn Health Science Institute
Oklahoma City, Oklahoma, United States, 73112
Pain Specialist of Charleston, P.A.
Mt. Pleasant, South Carolina, United States
Nashville Neuroscience Group
Nashville, Tennessee, United States, 37203
Trinity Clinical Research
Tullahoma, Tennessee, United States, 37388
ClinRx Research LLC
Plano, Texas, United States, 75080
Progressive Clinical Research
San Antonio, Texas, United States
Manna Research Vancouver
Vancouver, British Columbia, Canada, V6J 1S3
Manna Research, Inc.
Toronto, Ontario, Canada, M9W 4L6
Kells Medical Research Group - Manna Research
Pointe-Claire, Quebec, Canada, H9R 4S3
View full eligibility
Tris trial is registered with FDA with number: NCT01748877. The sponsor of the trial is NeurAxon Inc. and it is looking for 188 volunteers for the current phase.
Official trial title: A Double-Blind, Randomized, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia (PHN)
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