A multicenter observational pilot study will be conducted to determine the natural history of
infants with early diagnosis (≤ 6 hrs of age) of mild neonatal encephalopathy (NE) who are
not qualified for therapeutic hypothermia. The intervention includes: neurologic examination
by using modified Sarnat score at ≤ 6 hrs of age, 24 hrs and before discharge home,
amplitude-integrated electroencephalography (aEEG) at 6 ± 3 hrs of age, brain MRI at before
discharge home to 30 days of age and follow-up at 18-22 months of age. Primary outcome is the
percentage of mild NE infants with evidence of brain injury defined by the presence of at
least 1 abnormality of brain MRI, aEEG or neurologic examination in the neonatal period.
Secondary outcome is the percentage of brain MRI, aEEG and neurological exam abnormalities,
seizure, length of hospital stay, need of gavage feeds or gastrostomy at discharge home,
death and long-term outcome.