- The brain has natural rhythms called brain waves. An electroencephalogram (EEG) can record
these rhythms. When people identify the picture of a familiar object shown on a computer
screen, the communication between certain regions of the brain increases. An EEG can detect
these communication brain waves. Transcranial magnetic stimulation (TMS) can affect these
brain waves by slightly changing the brain s rhythms. Researchers want to see if changing
brain rhythms with TMS interferes with the ability to identify pictures of familiar objects.
This study will provide more information about how TMS can affect brain waves and behavior.
- To see if TMS can interfere with the brain s ability to identify pictures of familiar
- Healthy volunteers between 18 and 70 years of age.
- This study requires two visits to the clinical center. The first visit will last about 2
hours. The second visit will last about 4 hours.
- Participants will be screened with a physical exam and medical history.
- At the first visit, participants will have an object recognition test. Participants will
look at pictures of several objects on a computer screen. They will then have to state
whether the objects they see on the screen are familiar. The object recognition test
will be done along with TMS.
- At the second visit, participants will have an EEG while taking the object recognition
test. Brain waves will be monitored during the test. They will then repeat the test
while having repetitive TMS to study its effect on object recognition. The participants
will then take the object recognition test alone for a final time. This will make sure
that TMS effects (if any) on the ability to identify familiar object images are no