This trial is terminated!
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Your journey
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3Review
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More info
You can access this
clinical trial
if you have
T-cell Non-Hodgkin Lymphoma
and you are
between 18 and 70
years old
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

The current standard of care for the frontline treatment of peripheral T-cell lymphomas (PTCL) is induction chemotherapy followed by autologous stem cell transplantation (ASCT). However, many patients are unable to get to ASCT or relapse after ASCT, with a poor prognosis. Recently, a novel ASCT conditioning regimen of gemcitabine, busulfan and melphalan (Gem/Bu/Mel) has been reported to lead to favorable outcomes in this disease. We therefore designed a frontline regimen of CHOEP induction followed by Gem/Bu/Mel ASCT, and report the results of a phase 2 study of this regimen in patients with PTCL.

Provided treatments

  • Drug: Cyclophosphamide
  • Drug: Doxorubicin
  • Drug: Vincristine
  • Drug: Etoposide
  • Drug: Prednisone
  • Drug: Filgrastim
  • Drug: Plerixafor
  • Procedure: Stem Cell Collection
  • Drug: Palifermin
  • Drug: Gemcitabine
  • Drug: Busulfan
  • Drug: Melphalan
  • Procedure: Stem Cell Transplant

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01746173. The sponsor of the trial is Dana-Farber Cancer Institute and it is looking for 5 volunteers for the current phase.
Official trial title:
A Phase II Study of CHOEP Induction Followed by Gemcitabine/Busulfan/Melphalan Autologous Stem Cell Transplantation for Patients With Newly Diagnosed T-Cell Lymphoma