Pseudomonas aeruginosa is the main pathogen of nosocomial respiratory infections. Its
increasing resistance to antibiotics requires the development of new strategies for
prevention and control, demanding a better understanding of the modes of transmission and
evolutionary dynamics of this bacteria. In patients under invasive mechanical ventilation,
the main mode of contamination by Pseudomonas remains debated, with 3 modes of contamination
(endogenous, crossed transmission between patients, or environmental origin) of varying
importance, mainly depending on the endemic situation of the place of study.
The emergence of new genotyping technologies (DiversiLab) can now facilitate studies of
molecular epidemiology. Thanks to the multidisciplinary collaboration and innovative
techniques, the investigators wish to study the impact of the mode of contamination on the
outcome of ICU patients, intubated and ventilated for more than 72 hours.