1. The incidence of differentiated thyroid cancer is increasing in Korea. A significant
number of them experience severe hypothyroidism in preparation for radioactive iodine
(RAI) therapy after total thyroidectomy.
2. Because the function of thyroid hormone is closely linked with lipid and glucose
metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy may
induce the changes of metabolic parameters.
3. We investigate the effects of thyroid hormone withdrawal on metabolic and cardiovascular
parameters during radioactive iodine therapy in differentiated thyroid cancer.