Brain training exercises will be provided to children who survived an episode of severe
malaria. These children will be given assessments for cognition, behaviour and executive
functions before and after the brain training exercises.
Behavioral: Computerised cognitive rehabilitation training
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Full eligibility criteria for NCT01743417
Ages eligible for Study
5 Years to 12 Years
Genders eligible for Study
Accepts Healthy Volunteers
Aged 5 to 12 years of age;
Signed consent from the parent/guardian, assent from children aged 7 years and older;
Completion of their 24 months testing in the parent study (MUREC no 2008-033).
CM: elevated cerebrospinal fluid protein, white blood cells or red blood cells
Severe malarial anemia: history of coma, impaired consciousness, repeated seizures, other brain disorder, and developmental delay. Additional exclusion criteria for CC group:
any active illness; recent illness or recovery from illness;
chronic illness requiring medical care; -) medical abnormalities on screening history or physical exam.
All locations for NCT01743417
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Tris trial is registered with FDA with number: NCT01743417. The sponsor of the trial is Makerere University and it is looking for 300 volunteers for the current phase.
Official trial title: Computerized Cognitive Rehabilitation in Children After Severe Malaria
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