This study is a Phase 1 and pharmacologic open-labeled dose-escalation trial using a "3+3"
design, evaluating MM-141 at varying dose levels and frequencies.
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Locations near you
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Full eligibility criteria for NCT01733004
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Advanced malignant solid tumors for which no curative therapy exists that has recurred or pgrogressed following standard therapy
Eighteen years of age or above
Able to understand and sign an informed consent (or have a legal representative who is able to do so)
Measurable disease according to RECIST v1.1
ECOG Performance Score of 0 or 1
Adequate bone marrow, hepatic, renal and cardiac function
Willing to abstain from sexual intercourse or to use an effective form of contraception during the study and for 90 days following the last dose of MM-141
Active infection or fever > 38.5°C during screening visits or on the first scheduled day of dosing
Symptomatic CNS disease
Received other recent antitumor therapy
Pregnant or breast feeding
All locations for NCT01733004
United States (3)
Marietta, Georgia, United States
Boston, Massachusetts, United States
Detroit, Michigan, United States
View full eligibility
Tris trial is registered with FDA with number: NCT01733004. The sponsor of the trial is Merrimack Pharmaceuticals and it is looking for 42 volunteers for the current phase.
Official trial title: A Phase 1 Study of MM-141 in Patients With Advanced Solid Tumors
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