It is estimated that 350-400 million people worldwide are chronically infected with hepatitis
B virus (HBV). Cirrhosis and hepatocellular carcinoma are major complications of chronic HBV
infection and are responsible of about 500,000 deaths each year. Although some predictive
factors of the outcome of chronic HBV infection were reported, it remains needed to more
precisely determine the factors which are associated with the outcome in non-selected
patients. Indeed, these factors should help to identify patients who are likely to have a
better or worse evolution of their chronic HBV infection over time and thus, to adapt their
clinical management and monitoring.Therefore, our purpose is to constitute a "real-life"
cohort of non-selected patients to create a database of epidemiological, clinical,
biological, virological and therapeutic parameters, in order to determine factors associated
with the outcome of chronic HBV infection.