Brief Summary Cerebral Autoregulation is a well known physiological response to blood
pressure changes to maintain the cerebral perfusion. The critically ill patients are
submitted to different situations that can impair the cerebral autoregulation as sepsis,
sedation drugs and mechanical ventilation.
The delirium on ICU has been described as a bad prognosis factor, increasing the mortality
and length of stay. The physiopathology of delirium has been related to cerebral perfusion.
The delirium has been related to long term cognitive impairment.
Material and Methods:
This is a physiological prospective study that will be done in a 14 bed medical-surgical ICU.
The investigators will enroll 100 ventilated patients, septic and non-septic. The
investigators will measure cerebral autoregulation every 48-72 hours from admission on ICU.
Neurological biomarkers (Neurological Specific Enolase, S100 beta and Vascular Endothelial
Growing Factor) will be done at inclusion, 72 hours and 7 days. Clinical data, delirium
presence, analytic data and ventilatory parameters will be registered every day.
At hospital discharge, a psychologist will do a cognitive evaluation using specific tests.
The cognitive evaluation will be repeated at 3, 6 and 12 months.
Some items like mechanical ventilation, sepsis and sedation can impair cerebral
autoregulation. The impairment of cerebral autoregulation is related to delirium in ICU and
long cognitive impairment.