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More info
You can access this
clinical trial
if you have
Normal Physiology
and you are
between 18 and 49
years old
-
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

Background: - One form of the influenza vaccine is a nasal spray. It uses a live but weakened flu virus. Researchers want to better under how the live vaccine interacts with the body s immune system. They will test the nasal spray flu vaccine (called FluMist) against a saline (salt water) nasal spray. They will then look at blood and nasal cell samples to see how the vaccine affects these cells immune response. Objectives: - To look at immune changes in nasal and blood cells in people who receive live flu vaccine. Eligibility: - Healthy volunteers between 18 and 49 years of age. Design: - Participants will have five outpatient visits for this study. Each visit will last up to 2 hours. - At the first visit, participants will have a physical exam and medical history. They will give blood and urine samples. Nasal cell samples will also be collected. - A week later, participants will have either the nasal spray flu vaccine or a saline spray. They will know which spray they will receive. Blood samples will be collected. - Two days after the vaccination, they will have another physical exam. Blood and nasal cell samples will be collected. - At the final two visits (1 week and 1 month after the vaccination), more blood samples will be collected. - Those who had the saline spray will be able to have the actual vaccine spray at the last study visit. - The ratio of participants who receive vaccine to those who receive saline will be 4:1.

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01730144. The sponsor of the trial is National Institute of Allergy and Infectious Diseases (NIAID) and it is looking for 10 volunteers for the current phase.
Official trial title:
Elucidation of the Mucosal Immune Responses to Live Attenuated Influenza Vaccine In Healthy Adults