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More info
You can access this
clinical trial
if you have
Normal Physiology
and you are
between 18 and 49
years old
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

Background: - One form of the influenza vaccine is a nasal spray. It uses a live but weakened flu virus. Researchers want to better under how the live vaccine interacts with the body s immune system. They will test the nasal spray flu vaccine (called FluMist) against a saline (salt water) nasal spray. They will then look at blood and nasal cell samples to see how the vaccine affects these cells immune response. Objectives: - To look at immune changes in nasal and blood cells in people who receive live flu vaccine. Eligibility: - Healthy volunteers between 18 and 49 years of age. Design: - Participants will have five outpatient visits for this study. Each visit will last up to 2 hours. - At the first visit, participants will have a physical exam and medical history. They will give blood and urine samples. Nasal cell samples will also be collected. - A week later, participants will have either the nasal spray flu vaccine or a saline spray. They will know which spray they will receive. Blood samples will be collected. - Two days after the vaccination, they will have another physical exam. Blood and nasal cell samples will be collected. - At the final two visits (1 week and 1 month after the vaccination), more blood samples will be collected. - Those who had the saline spray will be able to have the actual vaccine spray at the last study visit. - The ratio of participants who receive vaccine to those who receive saline will be 4:1.

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01730144. The sponsor of the trial is National Institute of Allergy and Infectious Diseases (NIAID) and it is looking for 10 volunteers for the current phase.
Official trial title:
Elucidation of the Mucosal Immune Responses to Live Attenuated Influenza Vaccine In Healthy Adults