- One form of the influenza vaccine is a nasal spray. It uses a live but weakened flu virus.
Researchers want to better under how the live vaccine interacts with the body s immune
system. They will test the nasal spray flu vaccine (called FluMist) against a saline (salt
water) nasal spray. They will then look at blood and nasal cell samples to see how the
vaccine affects these cells immune response.
- To look at immune changes in nasal and blood cells in people who receive live flu vaccine.
- Healthy volunteers between 18 and 49 years of age.
- Participants will have five outpatient visits for this study. Each visit will last up to
- At the first visit, participants will have a physical exam and medical history. They
will give blood and urine samples. Nasal cell samples will also be collected.
- A week later, participants will have either the nasal spray flu vaccine or a saline
spray. They will know which spray they will receive. Blood samples will be collected.
- Two days after the vaccination, they will have another physical exam. Blood and nasal
cell samples will be collected.
- At the final two visits (1 week and 1 month after the vaccination), more blood samples
will be collected.
- Those who had the saline spray will be able to have the actual vaccine spray at the last
- The ratio of participants who receive vaccine to those who receive saline will be 4:1.