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You can access this
clinical trial
if you have
Advanced ENT Surgery or Microbiological Flora in the Oropharynx and Lower Airways
and you are
over 18
years old
Phase
-
The phase for this study is not defined.
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The purpose

Surgery in the mouth and oropharynx is performed in an area colonised by bacteria non-pathogenic and pathogenic. Antibiotics are used regularly resulting in disturbances in the intestinal microbiological flora and consequently diarrhoea that can be troublesome. The use of antibiotics throughout the hospital stay for these difficult cases represent a risk of development of resistant strains. Most of the patients have cancer diagnoses and have radiation therapy before surgery. This increases the risk of the patients having pathogenic bacteria normally present in the lower GI-tract. The investigators have shown for ICU patients that treatment with probiotics reduces the number of emerging enteral bacteria in the oropharynx and now the investigators will perform an adjusted procedure for patients planned for large ear, nose, and throat (ENT) surgery. Patients will preoperatively gurgle a suspension of probiotics and then swallow the preparation. Postoperatively the probiotics is given enterally and a eventually by mouth again. Cultures will be taken from the oropharynx and tracheal secretions and the results will be compared

Provided treatments

  • Dietary: L. plantarum 299 and L. plantarum 299v (+maltodextrin)
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Locations near you

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Tris trial is registered with FDA with number: NCT01730066. The sponsor of the trial is Region Skane and it is looking for 102 volunteers for the current phase.
Official trial title:
Probiotics for Reduction of Pathogenic Bacteria in Connection With Advanced Surgery in the Mouth, the Oropharynx, and on the Neck