Surgery in the mouth and oropharynx is performed in an area colonised by bacteria
non-pathogenic and pathogenic.
Antibiotics are used regularly resulting in disturbances in the intestinal microbiological
flora and consequently diarrhoea that can be troublesome. The use of antibiotics throughout
the hospital stay for these difficult cases represent a risk of development of resistant
Most of the patients have cancer diagnoses and have radiation therapy before surgery. This
increases the risk of the patients having pathogenic bacteria normally present in the lower
The investigators have shown for ICU patients that treatment with probiotics reduces the
number of emerging enteral bacteria in the oropharynx and now the investigators will perform
an adjusted procedure for patients planned for large ear, nose, and throat (ENT) surgery.
Patients will preoperatively gurgle a suspension of probiotics and then swallow the
Postoperatively the probiotics is given enterally and a eventually by mouth again.
Cultures will be taken from the oropharynx and tracheal secretions and the results will be