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More info
You can access this
clinical trial
if you have
Previously Treated Myelodysplastic Syndrome or Recurrent Adult Acute Myeloid Leukemia
and you are
over 18
years old
1
2
This is a medium phase trial determining
the safety and dosage of the new treatment, as well as its efficacy.
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The purpose

This phase I/II trial studies the side effects and best dose of decitabine followed by mitoxantrone hydrochloride, etoposide, and cytarabine and to see how well they work in treating patients with acute myeloid leukemia or high-risk myelodysplastic syndrome that has returned after a period of improvement or does not respond to treatment. Drugs used in chemotherapy, such as mitoxantrone hydrochloride, etoposide, cytarabine, and decitabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more cancer cells.

Provided treatments

  • Drug: Cytarabine
  • Drug: Decitabine
  • Drug: Etoposide
  • Other: Laboratory Biomarker Analysis
  • Drug: Mitoxantrone Hydrochloride
Tris trial is registered with FDA with number: NCT01729845. The sponsor of the trial is Fred Hutchinson Cancer Research Center and it is looking for 52 volunteers for the current phase.
Official trial title:
Mitoxantrone, Etoposide, and Cytarabine (MEC) Following Epigenetic Priming With Decitabine in Adults With Relapsed/Refractory Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndromes (MDS): A Phase 1/2 Study