This proposal aims to provide some objective, non-invasively achieved, physiologically
relevant data in order to provide some rational basis for decision-making for transfusion in
sTBI. Specifically this proposal is an observational study of transfusion and brain tissue
saturation in sTBI patients. The results will illustrate to what degree brain tissue
oxygenation is critically dependent on the degree of anemia in sTBI and help in the decision
of whether transfusion might be helpful.