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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Type 2 Diabetes or Depression
and you are
between 18 and 64
years old
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

The goal of the study is to examine the difference of the pharmacokinetics of metformin with and without a 3 weeks pretreatment of St John's Wort. Furthermore secondary objectives include changes in GLP-1, C-peptide, serum-insulin and plasma-glucose during an oral glucose tolerance test, changes in OCT1 mRNA in plasma and changes in leptin and lipid-profile following this possible interaction.

Provided treatments

  • Other: St John's Wort
  • Drug: Metformin

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01726764. The sponsor of the trial is University of Southern Denmark and it is looking for 20 volunteers for the current phase.
Official trial title:
Is There a Pharmacokinetic Interaction Between St John's Wort and Metformin?