The aim of the present study was to demonstrate the influences of three different treatment
strategies on biochemical parameters and testicular volume (TV) in patients with idiopathic
hypogonadotropic hypogonadism (IHH).
Drug: Testosterone enanthate (Sustanon 250 mg)
Drug: Human chorionic gonadotropin (hCG) (Pregnyl 5000 IU)
Drug: Testosteron gel (Testojel 50 mg)
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Full eligibility criteria for NCT01601327
Ages eligible for Study
18 Years to 30 Years
Genders eligible for Study
Accepts Healthy Volunteers
decreased serum testosterone concentration below the normal range (serum T < 300ng/dL),
FSH and LH levels within or below the normal range,
absence of a pituitary or hypothalamic mass lesions on MRI, presence of gonadotropin response to repetitive doses of GnRH,
normal smell test and normal karyotypes
previous androgen treatment,
history of smoking,
presence of bilateral anorchia,
arterial hypertension or dyslipoproteinemia,
medication of any kind and drug abuse. Because of possible confounding effects, patients with other hormone deficiencies were excluded. Participants with iron, vitamin B12 or folate deficiency were also excluded.
All locations for NCT01601327
Gulhane School of Medicine Dep. of Endocrine and Metabolism
Ankara, Turkey, 06018
Gulhane School of Medicine Dep. of Endocrinology and Metabolism
Ankara, Turkey, 06018
View full eligibility
Tris trial is registered with FDA with number: NCT01601327. The sponsor of the trial is Gulhane School of Medicine and it is looking for 119 volunteers for the current phase.
Official trial title: Effects of Three Different Medications on Metabolic Parameters and Testicular Volume in Patients With Hypogonadotropic Hypogonadism-Last Three Years Experience
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