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Your journey
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More info
You can access this
clinical trial
if you have
Hyperlipidemia
and you are
between 18 and 60
years old
2
3
This is an advanced phase trial assessing
the effectiveness of the new treatment before being released on the market.
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The purpose

Recent studies in both animals and humans has demonstrated that the hormone GLP-1 (glucagon like peptide 1) reduces intestinal production of lipoprotein particles. The investigators therefore hypothesise that the drug sitagliptin which prevents the breakdown of GLP-1 will reduce intestinal lipoprotein production in humans. The investigators are unable to speculate whether sitagliptin will affect hepatic lipoprotein production because of lack of of data from animal studies or in vitro data. Sitagliptin is already an approved treatment for type 2 diabetes.

Provided treatments

  • Drug: Sitagliptin
  • Drug: Placebo
Tris trial is registered with FDA with number: NCT01600703. The sponsor of the trial is University Health Network, Toronto and it is looking for 21 volunteers for the current phase.
Official trial title:
Sitagliptin (®Januvia) Regulation of Intestinal and Hepatic Lipoprotein Particle and Hepatic Glucose Production in Humans