Statins are commonly prescribed to lower cardiovascular risk in primary and secondary
prevention. Despite their well known efficacy, statin withdrawal is a common event. Even a
short term statin withdrawal can have dramatic consequences on atherosclerotic plaque
stability, owing to a rebound in cholesterol levels and inflammation.
The effects of a short term statin withdrawal on endothelial progenitor cells (EPC) and
monocyte/macrophage polarization is unknown.
In this study, the investigators will explore the effects of a 5-day statin withdrawal on EPC
and monocyte/macrophage polarization, together with other inflammatory biomarkers in type 2
diabetic patients. The investigators hypothesize that statin withdrawal determines a
reduction in EPC levels and an inflammatory cell polarization.
Patients will be randomized to continue their habitual statin regimen or to withdraw statin.
At baseline and 5 days later, blood samples will be collected for experimental measures.