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More info
You can access this
clinical trial
if you have
HIV Dementia
and you are
between 18 and 64
years old
3
This is a trial in the final phase before the treatment is released on the market.
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The purpose

This study is being done to see if a drug called long acting methylphenidate (Concerta) is safe and effective as a treatment for problems with mental function in adults infected with HIV. A subset of patients with HIV-associated memory loss have a defect in the speed with which they learn and process information. Methylphenidate drugs, such as Ritalin or Concerta, have been shown on tests to improve the ability to rapidly absorb information; these tests are called "reaction time tests". These drugs are already FDA-approved to treat Attention Deficit Disorders: ADD or ADHD. At baseline, all subjects get tests of memory and brain function; then they are split into two groups. One group on this study will receive Concerta for 2 weeks, and a second group will receive a placebo x 2 weeks. After that period both groups will receive memory and other tests of brain function, and then the groups will switch. The first group will receive placebo and the second will receive Concerta x 2 weeks, followed by more memory and neurological tests. After that all subjects will have the option to receive Concerta for free for 8 more weeks. At the last visit all subjects get memory and brain tests again.

Provided treatments

  • Drug: Long acting methylphenidate
  • Drug: Long acting methylphenidate
  • Drug: Matched placebo
Tris trial is registered with FDA with number: NCT01599975. The sponsor of the trial is University of California, Los Angeles and it is looking for 40 volunteers for the current phase.
Official trial title:
Phase III, Placebo-Controlled, Double-Blind Crossover Study of Slow-Release Methylphenidate (Concerta ™) for Treatment of HIV Associated Neurocognitive Disorder