The purpose of this study was to evaluate the effect of early administration of tranexamic
acid (TXA) on post partum hemorrhage caused by uterine atony after cesarean section delivery.
This was a randomised, placebo controlled trial including 74 patients. The investigators
included ASA1 parturients with correct haemostatic status undergoing cesarean section under
spinal anesthesia. The randomization begins after the inefficacy of oxytocin injections and
starting up sulprostone perfusion at the request of the surgeon. TXA Group received 10 mg/kg
of tranexamic acid as induction dose within 12 minutes and 1mg/Kg/h as maintenance within the
2 following hours. Placebo Group received same volumes of normal saline. The investigators
compared blood loss and transfusions in both groups.