Depression and anxiety accompany with advanced cancer. The effect of anti-anxiety depression
has not evaluated in special cancers. Mirtazapine is a drug anti-anxiety depression and has a
high risk increase weight. So the investigators assume Mirtazapine would not only improve the
anxiety and depression of metastasis pancreas cancer but also would improve the appetite of
such patients which would improve dyscrasia of pancreas cancer patients. The drug may improve
the quality of life in advanced pancreatic cancer which is of short survival.