Study in healthy males to assess bioavailability of single fostamatinib with iv micro tracer
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Full eligibility criteria for NCT01598571
Ages eligible for Study
18 Years to 55 Years
Genders eligible for Study
Accepts Healthy Volunteers
Healthy male volunteers aged 18 to 55 years (inclusive), with a weight of at least 50 kg and a body mass index (BMI) between 18 and 30 kg/m2 (inclusive)
Male volunteers willing to use barrier contraception ie, condoms with spermicide, from the first day of the investigational product administration until 3 months after the last administration of the investigational product
History of any clinically significant disease or disorder
History or presence of GI, hepatic, or renal disease or any other condition known to interfere with absorption, distribution, metabolism, or excretion of drugs
Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first administration of drug
Volunteers who smoke more than 5 cigarettes or the equivalent in tobacco per day
Any clinically significant abnormalities in clinical chemistry, hematology or urinalysis results as judged by the Investigator
All locations for NCT01598571
United Kingdom (1)
Ruddington, Nottingham, United Kingdom
View full eligibility
Tris trial is registered with FDA with number: NCT01598571. The sponsor of the trial is AstraZeneca and it is looking for 37 volunteers for the current phase.
Official trial title: A Study to Assess the Absolute Bioavailability of a Single Oral Dose of Fostamatinib With Respect to an Intravenous Micro Tracer Dose of [14C] R406 in Healthy Male Volunteers
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