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Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Elderly Metastatic Breast Cancer Population
and you are
over 60
years old
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

Chemotherapy and HER2 targeted agents can improve survival significantly in metastatic breast cancer. Chemotherapy however is associated with significant side-effects and can impact on Quality of Life and functionality in older patients. The investigators aim to establish HER2 targeted regimens with minimal toxicity in order to delay or even avoid the use of classical chemotherapy because of competing risks of death in this frail/elderly patient group.

Provided treatments

  • Drug: Pertuzumab + trastuzumab
  • Drug: Pertuzumab + trastuzumab + metronomic chemotherapy

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01597414. The sponsor of the trial is European Organisation for Research and Treatment of Cancer - EORTC and it is looking for 80 volunteers for the current phase.
Official trial title:
Pertuzumab + Trastuzumab (PH) Versus PH Plus Metronomic Chemotherapy (PHM) in the Elderly HER2+ Metastatic Breast Cancer Population Who May Continue on T-DM1 Alone Following Disease Progression While on PH / PHM: an Open-label Multicentre Randomized Phase II Selection Trial of the EORTC Elderly Task Force and Breast Cancer Group