The investigators are doing this research study to find out if giving a drug called
prasugrel, which is used to prevent blood clots, can reduce reactions to aspirin in people
with aspirin exacerbated respiratory disease (AERD), and to learn why taking aspirin every
day can work as a treatment for people with AERD. People with AERD have symptoms of asthma,
severe runny nose, polyps in the nose, and develop allergic reactions if they take
medications like aspirin.
People with AERD can be desensitized to aspirin in order to be able to safely use it daily,
but the investigators do not know if prasugrel may prevent reactions to aspirin and provide a
safer way for people with AERD to tolerate aspirin.
The investigators also want to understand what is different about the cells and urine from
subjects who have AERD, in comparison to subjects who have asthma but do not have AERD and
subjects who have allergic rhinitis but do not have asthma. Lastly, the investigators want to
understand how aspirin acts differently in subjects who have AERD, in comparison to subjects
who have asthma but do not have AERD.