Extra-renal sources of 1, 25-dihydroxyvitamin D can be increased to normal serum 1,
25-dihydroxyvitamin D levels in chronic kidney disease patients after administration of high
dose 25-hydroxyvitamin D. The investigators observed that 1, 25-dihydroxyvitamin D
concentrations were significantly increased after 3 months of omega-3 FA supplementation
compared to baseline levels without 25-hydroxyvitamin D administration in dialysis patients.
In this study, the investigators hypothesized that omega-3 FA and 25-hydroxyvitamin D
supplementations may increase 1, 25-dihydroxyvitamin D concentrations much more compared to
25-hydroxyvitamin D supplementation only in hemodialysis patients with insufficient or
deficient 25-hydroxyvitamin D levels.