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Your journey
1What's a trial
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More info
You can access this
clinical trial
if you have
Intestinal Obstruction
and you are
between 18 and 45
years old
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

The purpose of this study is to describe the effects of methylnaltrexone in preventing loperamide-induced delay of the oro-cecal and whole-gut transit time and measure pharmacokinetics of methylnaltrexone after subcutaneous and oral administration of immediate release and extended release capsules.

Provided treatments

  • Drug: Loperamide
  • Drug: Loperamide placebo
  • Drug: Methylnaltrexone placebo
  • Drug: Methylnaltrexone 12 mg sc.
  • Drug: Methylnaltrexone IR capsule
  • Drug: Methylnaltrexone ER capsule
  • Device: Colon Transit
  • Drug: Sulfasalazine

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01596777. The sponsor of the trial is University Medicine Greifswald and it is looking for 15 volunteers for the current phase.
Official trial title:
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects