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Your journey
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More info
You can access this
clinical trial
if you have
Intestinal Obstruction
and you are
between 18 and 45
years old
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

The purpose of this study is to describe the effects of repeated-dose methylnaltrexone in preventing loperamide-induced delay of whole-gut, oro-cecal and colon transit time and to measure pharmacokinetics of methylnaltrexone and naloxone-3-glucuronide after oral administration of methylnaltrexone and naloxone.

Provided treatments

  • Drug: Loperamide placebo
  • Drug: Loperamide
  • Device: Colon Transit
  • Drug: Sulfasalazine
  • Drug: Placebo of MNTX and NLX
  • Drug: Naloxone
  • Drug: Methylnaltrexone

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01596764. The sponsor of the trial is University Medicine Greifswald and it is looking for 16 volunteers for the current phase.
Official trial title:
Effects of Extended Release Methylnaltrexone Bromide (150 mg b.i.d.) in Comparison to Extended Release Naloxone Hydrochloride (20 mg b.i.d.) on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time in Healthy Subjects.