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Your journey
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More info
You can access this
clinical trial
if you have
Intestinal Obstruction
and you are
between 18 and 45
years old
1
This is an early phase trial to determine
the dosage and safety of the new treatment.
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The purpose

The purpose of this study is to describe the effects of repeated-dose methylnaltrexone in preventing loperamide-induced delay of whole-gut, oro-cecal and colon transit time and to measure pharmacokinetics of methylnaltrexone and naloxone-3-glucuronide after oral administration of methylnaltrexone and naloxone.

Provided treatments

  • Drug: Loperamide placebo
  • Drug: Loperamide
  • Device: Colon Transit
  • Drug: Sulfasalazine
  • Drug: Placebo of MNTX and NLX
  • Drug: Naloxone
  • Drug: Methylnaltrexone

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01596764. The sponsor of the trial is University Medicine Greifswald and it is looking for 16 volunteers for the current phase.
Official trial title:
Effects of Extended Release Methylnaltrexone Bromide (150 mg b.i.d.) in Comparison to Extended Release Naloxone Hydrochloride (20 mg b.i.d.) on Loperamide-induced Delay of the Oro-cecal, Whole-gut and Colon Transit Time in Healthy Subjects.