To compare the activity of AZD8931 against placebo on the cell markers in cancer tumours
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Full eligibility criteria for NCT01596530
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Females aged 18 or older Early stage breast cancer and planned surgery
Ineligible for Trastuzumab (Herceptin) treatment as per local guidelines
World health Organisation performance status of 0 to 1 Tumour size amenable to obtaining adequate biopsies pre dosing.
Eligible for Trastuzumab (Herceptin) Treatment Known sensitivity to AZD8931, its excipients or drugs in its class;
Including oral tyrosine kinase inhibitors History of eye conditions e.g. previous injury within 3 months or clinically significant eye disease
Concurrent malignancy Unable to discontinue medication or herbal supplement known to inhibit CYP3A4 or CYP2D6
All locations for NCT01596530
Korea, Republic of (2)
Seoul, Korea, Republic of
Yonsei, Korea, Republic of
View full eligibility
Tris trial is registered with FDA with number: NCT01596530. The sponsor of the trial is AstraZeneca and it is looking for 3 volunteers for the current phase.
Official trial title: A Randomised Double-Blind Placebo-controlled Multicentre Phase I Study to Assess the Biological Activity of AZD8931 in Patients With Early Breast Cancer Who Are Ineligible for Treatment With Trastuzumab as Defined by IHC Status
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