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Your journey
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More info
You can access this
clinical trial
if you have
Urinary Tract Infection
and you are
between 2 and 10
years old
2
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

The SCOUT study is a multi-center, centrally randomized, double-blind, placebo-controlled non-inferiority clinical trial. 746 participants will be enrolled over a 4.5 year period. 672 will be evaluated for the study's primary outcome measure. After the first 5 days of primary care physician initiated antimicrobial therapy, patients who are afebrile and asymptomatic will then be randomized (1:1) to the standard course therapy arm of 5 more days of the same antibiotic therapy or the short course therapy arm of a placebo for 5 more days (for 10 days total). The primary objective of this study is to determine if halting antimicrobial therapy in subjects who have exhibited clinical improvement 5 days after starting antibiotic therapy (short course therapy) have the same failure rate (symptomatic UTI) through visit Day 11-14 as subjects who continue to take antibiotics for an additional 5 days (standard course therapy).

Provided treatments

  • Drug: Cefixime
  • Drug: Cephalexin
  • Other: Placebo
  • Drug: Trimethoprim/Sulfamethoxazole

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01595529. The sponsor of the trial is National Institute of Allergy and Infectious Diseases (NIAID) and it is looking for 717 volunteers for the current phase.
Official trial title:
Targeted Clinical Trials to Reduce the Risk of Antimicrobial Resistance The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children"