1. Leutinizing hormone (LH) has been demonstrated to exert variable physiological actions
during menstrual cycle at appropriate plasma levels'
2. In early follicular phase,in the requisite range,LH is known to contribute to maturation
of oocyte during transition phase from metaphase-1(M1) to metaphase-2 (M2).
3. If during this transition, appropriate level of LH can be maintained either through the
use of gonadotropin releasing hormone (GnRH) antagonist if found excessive or
supplementation with exogenous LH, if found deficient, maturation process can be
4. Further maintenance of suitable combination of recombinant follicle stimulating hormone
(rFSH) + rLH can help in realizing higher yield of mature M2 oocytes,with higher
probability of establishing clinical pregnancy.