The purpose is to see how X-linked adrenoleukodystrophy (X-ALD) is associated with strength
and sensation using MRI, in women with X-ALD. The investigators will also see whether
exercise can improve these symptoms for women with X-ALD.
Behavioral: exercise training
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Full eligibility criteria for NCT01594853
Ages eligible for Study
21 Years to 70 Years
Genders eligible for Study
Accepts Healthy Volunteers
confirmed diagnosis, X-ALD heterozygote carrier
no medical contraindication to participating in a strength training program
able to follow complex directions as determined by a score of ≤1 on a subset of questions taken from the NIH Stroke scale (Brott et al. 1989)
hip flexion strength: 6.6-15.8kg
hip extension strength: up to 18.3 kg
normal passive range of motion at hips/knees/ankles
able to walk ≥50m
Evidence of other neurological deficit that could interfere, such as previous stroke or muscle disease
congestive heart failure
severe pain that precludes study participation
other medical condition that precludes participation in an exercise program, e.g., unstable angina, uncontrolled diabetes, uncontrolled hypertension Healthy controls have the same age and exclusion criteria as women with AMN except that they will not be carriers for X-ALD. They must have normal neurological function.
All locations for NCT01594853
United States (1)
Motion Analysis Lab
Baltimore, Maryland, United States, 21205
View full eligibility
Tris trial is registered with FDA with number: NCT01594853. The sponsor of the trial is Hugo W. Moser Research Institute at Kennedy Krieger, Inc. and it is looking for 31 volunteers for the current phase.
Official trial title: Exercise Study of Function and Pathology for Women With X-ALD
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