The Cardiovascular Inflammation Reduction Trial (CIRT) is a randomized clinical trial
investigating whether taking low-dose methotrexate reduces heart attacks, strokes, or death
in people with type 2 diabetes or metabolic syndrome that have had a heart attack or multiple
coronary blockages. This trial is funded by the National Heart, Lung, and Blood Institute
(NHLBI)/National Institutes of Health (NIH).