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Your journey
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More info
You can access this
clinical trial
if you have
Post Operative Pain or Hyperalgesia
and you are
between 18 and 75
years old
The phase for this study is not defined.
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The purpose

Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.

Provided treatments

  • Drug: ketamine infusion
  • Drug: Methadone PCA

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01594047. The sponsor of the trial is Fondazione IRCCS Istituto Nazionale dei Tumori, Milano and it is looking for 96 volunteers for the current phase.
Official trial title:
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone