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Your journey
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More info
You can access this
clinical trial
if you have
Post Operative Pain or Hyperalgesia
and you are
between 18 and 75
years old
-
The phase for this study is not defined.
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The purpose

Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.

Provided treatments

  • Drug: ketamine infusion
  • Drug: Methadone PCA

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01594047. The sponsor of the trial is Fondazione IRCCS Istituto Nazionale dei Tumori, Milano and it is looking for 96 volunteers for the current phase.
Official trial title:
Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone